Carlos V dreamed of creating a universal monarchy capable both of guaranteeing a peaceful political order, having its moral and religious foundation in catholicism, and of forming an insurmountable barrier with which to oppose the expansion of the Ottoman Empire. However, his dream could not be fulfilled.
In 1519 he was elected Holy Roman emperor and in 1530 Pope Clemente VII crowned him king of Italy.
In 1536, the emperor took direct possession of Milan and began the war, first against Francisco I and his allies, and then against his son, Enrique II. The peace of Cateau-Cambrésis of 1556 sanctioned the hegemony of Spain over Italy.
Proof of its passage through Crotone is the modification that the severeign imposed in 1541 on the castle built in the heart of the city in 840 to defend it from saracen inasions. Today the buiding represents one of the largest fortresses in southern Italy and is called, in fact, the castle of Carlos V. Inside it houses the civic museum of Crotone and the municipal library.